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Puppy itching after NexGard. Is this normal or should I switch brands?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | neutered | 4 months and 7 days old | 18 lbs

NexGard seems to make our puppy itch. We have only had him 2 weeks, he does not have fleas. We gave him his monthly pill as instructed by the Vet and he is itching now. Is that ok or should we switch brands for next month? 18 pound spaniel-terrier mix. About 4 months old.

3 Answers

Most Helpful Answer

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Answered By Ricardo Fernandez, DVM

Veterinarian, Veterinary Oncology Resident

Published on May 7th, 2018

Thanks for using Petco Pet Education Center, formerly Petcoach! I would not recommend that you switch him yet as this may be completely coincidental. Nexgard is a great preventative and I would give it more time before switching to something else. Hopefully the scratching is not a reaction to it as that would be quite unusual. If the itchiness continues despite giving it a few days, that would likely be due to allergies rather than a cause of using Nexgard. It really comes down to figuring out what is causing his allergies so that they can be treated or the specific allergen avoided. A secondary infection is likely and also needs to be addressed. There are many things that can cause allergies though in most cases they can be broken down into 3 big categories: flea, food and environmental allergies. Allergies are usually worked up in a stepwise fashion starting with flea allergies as this is the easiest and cheapest to take care of. If not on a flea preventative, then it would be a good idea to get started on one. If already on one then it would be a good idea to change to something else (there are many new products out in the market). If not improved in 1-3 months then it is time to move on and check for food allergies by switching to a novel diet (new protein and new carbohydrate). If that does not seem to be the issue then you are left out having to check for environmental allergies which require blood and/or skin tests. Allergies can be very frustrating to deal with at first but so rewarding at the end when we are able to treat them effectively!

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5Pet Parents found this answer helpful

Related Answers from Veterinarians

  • Published on August 3rd, 2017

    This is probably due to an allergy, although it could also be infection or mites. First of all, in order to rule out skin parasites, you will need to treat with a high quality flea treatment (advocate or advantage), then ask the vet to perform a skin scrape - this might reveal an infection or a mite infestation. If all of those came back negative, the next step is to treat the allergy symptomatically and try to discover the cause of the allergy. Three main type of allergies are usually affecting pets: food allergies, flea and parasite related ones and environmental type (allergens coming from trees, pollens, dust etc etc). Some medications can be given by the vet in order to repair any possible skin lesions (like steroids and antibiotics). Please do not hesitate to contact us again on the forum or by requesting a consultation if you have any more questions or to discuss it any further.

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    2Pet Parents found this answer helpful

  • Published on May 21st, 2018

    This is probably due to an allergy, although it could also be infection or mites. First of all, ask the vet to perform a skin scrape - this might reveal an infection or a mite infestation. If all of those came back negative, the next step is to treat the allergy symptomatically and try to discover the cause of the allergy. Three main type of allergies are usually affecting pets: food allergies, flea and parasite related ones and environmental type (allergens coming from trees, pollens, dust etc etc). Some medications can be given by the vet in order to repair any possible skin lesions (like steroids and antibiotics). Hope this answer was helpful, but please do not hesitate to contact us again on the forum or by requesting a consultation if you have any more questions or to discuss it any further.

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    1Pet Parents found this answer helpful

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