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Dog sick from Trifexis? What's an effective, low-side-effect option?

Updated On September 23rd, 2025

Pet's info: Dog | American Cocker Spaniel | Female | spayed | 6 months and 21 days old | 13 lbs

I just gave Sophie her Trifexis and even though she is now 7 months, she still has the same side effects from the pill. Lethargy, upset stomach, and general feeling miserable. She had worm issues when she was a few months younger and dont want that to return. Is there another product that works as well as this for all she needs but less side effects?

1 Answer

Most Helpful Answer

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Answered By Megan, DVM, CVA

Veterinarian

Published on May 7th, 2018

I definitely would not continue giving Trifexis if she is continuing to have this reaction every month even if you give it on a full stomach. This is not normal and I have seen these reactions only get worse with time. I would strongly recommend you to switch her to something else like heartgard plus, advantage multi, or even the proheart injection. I would talk to your vet about what they recommend depending on the type of worms she had in the past. Different heartworm preventions work to prevent different types of worms. I hope this helps!

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