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What are bordetella intranasal vaccine side effects and what to do?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Male | neutered | 2 months and 4 days old | 13 lbs

He’s getting bordetella vaccine intranasaly today. What are some side effects that I should worry about if I see and how fast do they typically occur? I have antihistamine dosage for him, should I give if there is any reaction?

1 Answer

Most Helpful Answer

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Answered By C. Rathjens, DVM

Veterinarian

Published on April 5th, 2018

Congratulations on your new pup! The bordetella intranasal vaccine is not one that we regularly see reactions to, so it would be pretty surprising to have a vaccine reaction, although I suppose not impossible. Signs of a vaccine reaction include major facial swelling, vomiting, and extreme lethargy. If you saw any of these issues after his vaccine, or any vaccine, I would recommend giving an appropriate dose of Benadryl (the dose depends on his body weight and your veterinarian can tell you how much you should give) and taking him to a veterinary emergency clinic. However, with the intranasal bordetella vaccine you are more likely to just see a little bit of sneezing in the day or two after the vaccine. That is not a vaccine reaction does not require any treatment. I hope that helps and that you have a good appointment today! Thanks for using Petco Pet Education Center, formerly Petcoach.

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