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How long after Frontline can I safely give my cats Advantage?

Updated On September 23rd, 2025

Pet's info: Cat | Domestic Longhair | Female | spayed | 15 years old | 7 lbs

Hi there we gave our cats frontline on sep 7th still had a huge flea issue. vet said we could re apply on sept 21 and we are still seeing a lot of live fleas on the cats! When would it be safe to give them advantage?

1 Answer

Most Helpful Answer

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Answered By Andrea M. Brodie, DVM

Veterinarian

Published on September 29th, 2018

You should be able to give the advantage (for cats) about 10 days after having reapplied the Frontline. However there is more you need to do to get rid of fleas: Unfortunately fleas only hop on the body of your pet when they want to feed, then they hop off again and stay in your pet's environment. So you need to treat all pets in the household as well as the environment (which contains the fleas, their eggs and larvae). Flea treatment:  1) Get some flea medication such as a Flea spray or a spot on from a pet shop or your veterinarian and apply monthly (as you have done) 2) get flea powder, put some in your vacuum cleaner bag and vacuum your house and furniture and also non-carpeted areas frequently to remove flea larvae and eggs which live off house dust., Dispose of the bag in the trash outside. Hot-wash all the pet's bedding, If you do this diligently for a few months you will get rid of the fleas. Flea products: Spot-ons and/or chews Advantage, Advantix Advantage Multi (Advocate in the UK) Frontline (ticks as well) Bravecto spot on (ticks as well) - for cats, in tablet form for dogs Simparica, Nexgard Revolution (stronghold in the UK) Tablets: comfortis (will only kill fleas once) Collar: Seresto (ticks as well)

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