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My outdoor cat's flea meds aren't working. How do I safely switch?

Updated On September 23rd, 2025

Pet's info: Cat | Domestic Shorthair | Female | spayed | 10 lbs

Hi ! I'm having a challenge getting my outdoor kitty's flea problem under control . AdvantAge works for a week then stops working. Is it safe to try frontline two weeks after applying advantage ? Was also thinking of trying comfortis but am afraid of any side effects because it's internal . In your experience , Does frontline work well? Is a topical any less toxic than an internal? I had to give her drontal about a week and a half ago so I don't wanna overload her system . Thank you

1 Answer

Most Helpful Answer

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Answered By Lindsey Edwards MVB, BSc, IVCA

Veterinarian

Published on June 9th, 2018

I have found oral preventives to be more effective that topicals and equally as safe. The most important thing when treating fleas however is to break the flea life cycle by inactivating the eggs and larvae which comprise 95% of the flea burden (only 5% are active adults at any one time) - you will continue to see live fleas as they hatch and before they are killed by treatment. I recommend disposing of as much bedding etc as possible and spraying all sleeping areas and resting places with an insecticidal household flea spray such as acclaim or indorex in order to inactivate the eggs

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