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Is Sildenafil dose safe for dog with heart and kidney issues?

Updated On September 23rd, 2025

Pet's info: Dog | Chihuahua | Male | neutered | 14 years old | 5.4 lbs

My dog was just prescribed Sildenafil for pulmonary hypertension. He is also in Kidney failure. The dose is 0.5ml twice a day. He is 5.4 pounds. I have a few questions I'd like to confirm. 1. Is the dose correct? (0.5ml 2x a day - he is 5.4lbs) 2. Are there any side effects that I should look out for especially due to the kidney Failure? 3. How quickly would it take effect in helping his breathing? 4. Is this drug hard on the kidney? Thanks!

1 Answer

Most Helpful Answer

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Answered By Linda G, MS, DVM

Veterinarian

Published on February 23rd, 2018

Hello. You do not indicate how many mg are in an ml of your medication, so you will need to look on your bottle. For example, it should say something like 10mg/ml, so 0.5 ml will contain 5 mg of the drug. There is a range of doses, but this is what would be acceptable for a 5.4-pound dog, 2.5 - 7.4 mg every 12 hours. It is very safe to give to a pet with kidney failure as this medication only affects pulmonary artery pressure & perfusion. Side effects are actually not well known but include inguinal ( groin ) flushing & perhaps some GI distress ( diarrhea ). Hopefully, it helps his breathing within a few days, but if not, dosage adjustments are often made. Stay in close touch with your veterinarian as to how Memi responds to his treatments. Thanks for using Petco Pet Education Center, formerly Petcoach.

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