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What safe OTC medication can calm my anxious dog for air travel?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | neutered | 3 years and 11 months old | 29 lbs

The need has arisen to transport our dog on an airplane (will be in cabin), a first for our dog. He can get very anxious in new surroundings and doesn't have patience to sit still very long. Is there a safe OTC supplement or medication to give him to calm him for the trip? I've heard Benadryl is an option but I don't just want to give him dose of medication meant for humans and hope it works the way I want it to.

1 Answer

Most Helpful Answer

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Answered By Dr. Strydom, DVM

Veterinarian

Published on April 16th, 2020

You can give Dramamine which would be better than Benadryl. Regular Dramamine, not non-drowsy. The active ingredient should be dimenhydrinate. Dogs take a higher dose than humans do so don't be alarmed. It is 4mg per pound of body weight so at about 30 pounds he needs 120mg. They come in 50mg tablets. So, I would give two tablets (100mg). Do a trial at home first with the medication to see how it affects him. When traveling it is recommended to give it at least one hour (90-120 minutes would be best) prior to leaving the HOUSE. You can re-dose it every 8 hours as needed. Again, please try it at home first to see how he does with it.

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