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My dog is sick after lepto and DAPPv shots. What are the side effects?

Updated On September 23rd, 2025

Pet's info: Dog | Yorkshire Terrier | Male | neutered | 10 years and 3 months old | 6 lbs

Zues got his lepto and dappv shot today now he seems a little under the weather is there side affects of these shots?

1 Answer

Most Helpful Answer

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Answered By Jennifer Ladd, DVM

Veterinarian

Published on August 4th, 2018

Vaccine reactions can vary widely, similar to humans. Mild symptoms include injection site tenderness, and transient lethargy (24 hours or so). Contact you veterinarian if lethargy persists, he stops eating, vomits, or has diarrhea. Emergency intervention would be respiratory distress, swollen face or a severe change in temperament due to fever/ more severe illness than listed above. These types of reactions are very rare. For my patients that show even mild vaccine reactions, I will reduce their vaccines to 1 booster per visit, and often will pre-medicate with Benadryl. I also prioritize my vaccines based on age of the animal, vaccine history and prevalence of disease in our region.

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