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My cat has megacolon, can't poop, and won't eat. What should I do?

Updated On September 23rd, 2025

Pet's info: Cat | Mixed Breed | Female | 7 years and 8 months old | 8.5 lbs

My 8 year old, female, spayed, cat has a megacolon and cant pass any stool. She has been on lactulose for 2 days, has had 3 enemas, and fluids administered under the skin. Yet she still hasnt been able to pass anything despite trying and now she wont eat. Is there something else that can be done before resorting to a colonoscopy?

2 Answers

Most Helpful Answer

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Answered By Laura Johnson VMD

Veterinarian

Published on July 5th, 2018

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Poor Galaxy! I recommend cisapride, lactulose and Royal canine fiber response for constipated cats. Sometimes with the prescription diet it eliminates the need for most medications. If she isn't eating I would have her seen today and deobstipated (sedate and remove all feces) before the weekend. Then get the cisaride and food started. Sometimes refractory cases need partial removal of their colons. I wish you the best!

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Other Answers

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    Answered By Laura Johnson VMD

    Veterinarian

    Published on November 8th, 2017

    Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Poor Kitty! The images of the X-rays came over in too poor quality to evaluate. I would try to treat Kitty medically first with lactulose (stool softener), miralax, high fiber diet and cisapride (motility agent). If medical management doesn't work then I would discuss a subtotal colectomy with your Vet. Though my concern would be for progressive neurologic signs due to her spinal changes. You could discuss steroids with your Vet as well. I think it's going to be a lot of trial and error to find the perfect medical combination for Kitty. That is the case with many megacolon cats. I hope this helps and I wish Kitty the best!

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