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My senior dog has enlarged liver, losing weight. What's wrong?

Updated On September 23rd, 2025

My dog has an enlarged liver. He is uncomfortable a lot. The vet thought that he had cushings but the test was negative and although he is always hungry he leaves his kibble in the bowl without eating it. He is on pain meds for his joints, but he is moaning now at night. And he is eating a lot ( he is 13 and we are just letting him have some extra food - he gets 3 cans of food a day instead of 2.5 - and he goes some treats) but he is pooping everything out. What could be wrong with him?

1 Answer

Most Helpful Answer

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Answered By Stacey Anstaett, DVM

Veterinarian

Published on July 3rd, 2018

I'm sorry your dog isn't feeling well. Regarding your comment about leaving kibble in his bowl without eating it, yet still eating 2 cans of food a day and some treats--it sounds like he is getting enough food and appetite is not a problem. When you say he is "pooping everything out," is he having diarrhea? Or does it seem that he is losing weight even though he is eating a lot? Or is he pooping very frequently? To review the list of problems/symptoms that you have given: *losing weight even though he is eating a lot (if this is what you mean by "pooping everything out") *uncomfortable/moaning *enlarged liver *blood test negative for Cushings disease Considering that he is 13, given the problem list above one of the biggest things I would worry about is cancer of some kind, and arthritis may be contributing to his discomfort. Unfortunately there is not any ONE test for cancer, so its not something your vet can just submit a blood sample and get an answer for. If you are wanting to KNOW what her diagnosis is, your vet will need to run full lab work (a full chemistry profile, a complete blood count, and a urinalysis), take X-rays of his chest, and probably perform an abdominal ultrasound (sonogram of the belly) as well. If an abnormality is discovered on X-rays or ultrasound, a biopsy may needed. Regardless of the cause, and even if you don't have funds to do a lot of diagnostics, you can focus on making him comfortable, with the understanding that his time may be limited. Ask your vet about pain medications. Don't worry about him not eating kibble--if he prefers canned food that is fine. I'm sorry I cannot give you black and white answers as to what is wrong. But he's a very lucky boy to have someone who cares so much for him. Wishing you both the best. Thanks so much for asking Petco Pet Education Center, formerly Petcoach.

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