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My dog ate ibuprofen. How long until poisoning symptoms start?

Updated On September 23rd, 2025

Pet's info: Dog | Pembroke Welsh Corgi | Female | spayed | 25 lbs

How long would it take for symptoms of toxicity to kick in to my 25-30 pound dog after eating a 200 mg ibuprofen? It has been about an hour and a half since she possibly took it and she's been fine, no loss in appetite or (seemingly) no upset stomach.

4 Answers

Most Helpful Answer

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Answered By Vanessa Yeager DVM MPH

Veterinarian

Published on November 7th, 2017

Hi there and thanks for posting. Ibuprofen has a narrow margin of safety in dogs and cats. Based on Sadie's weight, she may have received 18mg/kg which is below the toxic dosage in dogs. However, dogs can be very sensitive to this drug, even at small dosages. Sometimes onset of symptoms can be immediate (1-4 hours after ingestion) or can be be delayed for a day or two. It depends on the pet and how much was consumed. Please keep an eye out for vomiting, diarrhea, blood in the vomit, increased urination, increased thirst or any other behavioral change and take Sadie to an emergency veterinary clinic if you see any of the above signs. If you are still concerned and need further guidance, please contact the Pet Poison Helpline at 855-764-7661. I hope this helps and thanks for posting on Petco Pet Education Center, formerly Petcoach!

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    Answered By Jennifer Summerfield, DVM CPDT-KA

    Veterinarian, Certified Dog Trainer

    Published on June 27th, 2021

    Normally, the toxic dose for ibuprofen in dogs is considered to be 25 mg/kg or higher for GI issues (such as stomach bleeding, gastric ulcers, vomiting, etc.), and 100 mg/kg or higher for kidney damage. If your dog is about 15 lbs, this would make her around 6.8 kg. So a 100 mg dose in a dog this size works out to around 15 mg/kg, which should be below the typical toxic dosage range. So as long as she doesn't have any underlying health issues and isn't on any other meds that might interact with the ibuprofen (such as Rimadyl, Metacam, prednisone, etc.), it's unlikely that you'll see any problems, especially if it's been about 48 hours so far and she's not showing any ill effects. But for sure, definitely make sure your mother-in-law knows to avoid this medication for dogs in the future! Ibuprofen is not a safe choice for pain control in veterinary patients, and is never recommended. To be on the safe side, I would watch Remi for the next few days for any signs of GI upset or stomach bleeding (vomiting, not eating, dark tarry stools, etc.), and take her to the vet to be seen if there are any concerns.

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    Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on February 24th, 2019

    Consumption of ibuprofen by your dog can result in serious complications and does warrant an emergency visit to your local veterinarian. Complications can consist of internal bleeding and damage to liver and kidneys just to name a few. Do not wait to take your pet to see a veterinarian until you see external symptoms of toxicity. Symptoms that include vomiting, diarrhea, pale gums, and abdominal pain are shown only when systemic function has already been compromised. A single 200-miligram tablet is enough to cause damage to internal organs in your pet, and Grizzly has eaten two of them. Again, this does require an emergency visit to your local veterinarian. Best of luck.

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    Answered By David Elbeze, DVM, MRCVS

    Veterinarian

    Published on June 25th, 2017

    Doses of 25 mg/kg or more often lead to gastrointestinal (GI) problems and ulceration, manifested as vomiting, diarrhea, or abdominal pain. Doses approaching 175 mg/kg increase a dog's risk of developing acute renal failure. to protect the stomach from potential ulceration you can use Famotidine 10mg which is OTC (once a day).

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