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My dog's liver is bad from pheno. Will Keppra control seizures?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Small (up to 22lb) | Male | neutered | 8 years and 7 months old | 13 lbs

My dog Yogi is 8.5 years old and has been on phenobarbital 32.4mg and potassium bromide 1mg for 6 years to control his epilepsy. He has his liver levels tested every 6 months and we just got the results back that his liver is suffering as a result of the pheno. My vet wants to take him off the pheno and put him on keppra and also keep with the potassium bromide. His seizures are currently under control, but I am worried that the keppra will not work as well. Has anyone had experience switching f

1 Answer

Most Helpful Answer

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Answered By Linda G, MS, DVM

Veterinarian

Published on October 12th, 2017

Hello, & thank you for using Petco Pet Education Center, formerly Petcoach. Keppra is an excellent anti-seizure medication used extensively in human & veterinary medicine. The advantage to keppra over phenobarb, is the keppra is metabolized unchanged by the body, thus the liver does not ever see it.. Therefore, it is an excellent drug when the liver has become compromised by the phenobarb. Not every dog needs to be switched, but when they are, the seizures are very well controlled. Hope this helps.

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