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Trifexis failed. What's the best flea prevention to switch my dog to?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Male | neutered | 10 lbs

My 2 small dogs have been Trifexis for the past 1 to 2 years but last month it stopped working & they're covered in fleas! What should I switch to?

1 Answer

Most Helpful Answer

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Answered By Lauren M. Jones, VMD

Veterinarian

Published on June 28th, 2017

Oh no! Fleas are not a fun surprise! Trifexis prevents fleas, heartworms and some intestinal parasites. Since this isn't working for you, I typically recommend using either Nexgard, Bravecto or K9 Advantix II as flea and tick prevention. Please note that Nexgard and Bravecto are prescription-based (like the Trifexis), so these would need to be obtained by Prince's vet. Prince and his friend will also need to start a separate heartworm prevention, such as Heartgard or Interceptor, but again, these are prescription-based. Until you can pick up these new medications, you can bathe both dogs in original blue Dawn dish soap because this will help to kill the existing adult fleas. I hope this helps and that all goes well!

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