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My senior dog has high liver enzymes. Is Denamarin the only option?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Large (61lb +) | Male | neutered | 64 lbs

My German Shepherd mixed breed is around 13. (Pound dog - exact age unknown.) He is being treated fro a suspected pinched nerve in his back. The Vet suggested routine blood work. Two markers in the Catalyst Dx section were high. ALT was 180 U/L (normal 10-125) and ALKP was 492 U/L (normal 23-212). She said to help his liver he should get Denamarin 425 mg, one pill per day. It is very expensive. I have no reason to doubt her integrity or competence, but.... Do you agree?

1 Answer

Most Helpful Answer

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Answered By Tomasz Wnuk

Veterinarian

Published on May 7th, 2018

The results suggest liver inflammation/ mild damage to some the the liver cells. It could be due to infection, mild intoxication, chronic hepatitis etc. As the results are not veyr high, the best way to treat is the provide supplements to speed up liver recovery and re-test the liver enzymes in 4-5 weeks. You should get for Grissom food supplement containing SAMe, (you will find more on SAMe here: https://www.petcoach.co/article/s-adenosylmethionine-same-an-aid-to-managing-liver-disease/ ). Denosyl is a very good supplement containing SAMe but you will probably find cheaper options at your vets, pet shops or online.

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