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Should I use Benadryl or melatonin for my dog's flight anxiety?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | neutered | 50 lbs

My dog has anxiety seeing other dogs. He isn’t aggressive, he just wants to play. He whines, and sometimes barks but very rarely. We have a trip to fly to Vegas this summer. I heard Benadryl is safe for him for anxiety and motion sickness. Is this correct? Is melatonin better?

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1 Answer

Most Helpful Answer

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Answered By Daniel Fonza, DVM

Veterinarian

Published on April 10th, 2018

I find that for over the counter products, melatonin works much better than Benadryl for most dogs in my experience. The product I would recommend trying for Marco is NaturVet Quiet Moments Calm Chews with Melatonin, which can be found online or at your local PetCo quite easily. I hope this helps! Please let me know if you have any other questions or concerns and I would be more than happy to help you further.

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