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My cat has stomatitis and pain. Is Depo-Medrol a safe treatment?

Updated On September 23rd, 2025

Pet's info: Cat | Mixed Breed | Female | spayed | 8 lbs

My cat has stomotitus and is in cronic pain. Her teeth have been pulled with the exception of her fangs and a few in the very front of her mouth. Before the tooth extraction she was getting depomedrol shots. They worked great and would last a month. She can only have injectable medications. The tooth extraction did not help her. She has been taking vetalog and convenia because my new vet is against depomedrol. They are not working. Should I take her somewhere else? How harmful is depomedrol?

1 Answer

Most Helpful Answer

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Answered By Dr. Elizabeth

Veterinarian

Published on May 25th, 2019

I hate to hear that Gotham is having so many problems. Steroids can be very detrimental to the health but this is highly variable among individuals. Steroids affect the adrenal axis, the liver and can predispose to conditions such as diabetes. Other factors such as longer acting steroids and frequency of administration can influence the side effects. If she does not appear to be getting better with the current treatment, you may want to do a few things. Certainly a specialist would be beneficial and you could ask for a referral. Gotham should also have full mouth radiographs to check for any retained tooth roots as these can continue to be a problem. Lastly, looking into medications that function on the immune system itself such as Cyclosporine maybe worth a try. I hope this helps.

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