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My cat reacted to Seresto. When can I use Frontline or other topical?

Updated On September 23rd, 2025

Pet's info: Cat | Mixed Breed | Male | neutered | 12 lbs

My cat had a reaction to the Seresto flea and tick collar. When should I administer a topical medication like Frontline Plus for Cats?

1 Answer

Most Helpful Answer

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Answered By Lauren Kennedy, DVM

Veterinarian

Published on May 13th, 2019

I would wait until the skin reaction from the collar has completely healed before putting another topical medication on the skin. I would recommend asking your vet if you can give a dose of Comfortis this month. It is an oral flea prevention so you won’t have to worry about the skin at all. I hope this helps. Thanks for using Petco Pet Education Center, formerly Petcoach. Best of luck.

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