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My cat on Semintra has a nosebleed. Should I skip her dose tonight?

Updated On September 23rd, 2025

Pet's info: Cat | American Shorthair | Female | spayed | 8 lbs

My diabetic cat has kidney disease, scarred kidneys, inflamed intestines, too much protein in urine. An ultrasound done yesterday confirms all of this. They couldn't do a intraglomerular blood pressure test, but guessed she likely has high blood pressure. They sent me home with Semintra, a blood pressure medication. She had a dose last night, a dose this morning. Appetite and drinking are fine, she seems normal, but has a nosebleed. Should I not give her dose tonight? My vet is closed till morn.

1 Answer

Most Helpful Answer

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Answered By Dr. B. DVM, DACVIM (Oncology)

Veterinarian

Published on April 11th, 2019

Although a nose bleed does not appear to be a common side effect since it occurred after starting this medication it would be best to skip a dose until you can talk to your vet. It is also concerning to start a medication like this without having a baseline blood pressure. This would be systemic blood pressure taken like a person with a cuff. This drug has not been studied in cats with extremely high blood pressure and would also be contraindicated with normal blood pressure. Not all cats with kidney disease have high blood and there are numerous causes for protein in the urine. Was the protein loss determined to be significant? In order to know this a test called a urine protein:creatinine ratio is needed. Protein loss in the urine can not be determined as significant based off a screening urinalysis alone. I hope this helps and thank you for using Petco Pet Education Center, formerly Petcoach!

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