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Is the 1-year or 3-year rabies vaccine safer for my indoor cat?

Updated On September 23rd, 2025

Pet's info: Cat | Domestic Shorthair | Female | spayed | 7 years and 6 months old | 8 lbs

Whats the pro &cons of a 1 yr & 3 yr rabies vac on cats. My sassy is 7 and at a old vets office got the 3 and the current vets, a tech told me that the 1 yr pure vac was safer. I dont want too many vacs on my cats since they are all indoors. Also i read some vacs actually last longer in the system then the year or 3 that are given. Thank you.

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Answered By Daniel Fonza, DVM

Veterinarian

Published on January 7th, 2019

For the 1yr Rabies vaccination, this is generally formulated using a particular carrier for the vaccination that is safer than the 3 yr Rabies vaccination. The canary pox virus is the carrier for the Rabies 1 yr and is generally touted as being safer with less of a chance to stimulate an adverse reaction / trigger vaccine associated tumors. I typically recommend the 1yr Rabies vaccine and rarely use the 3yr. We might use the 3yr vaccination if we run out of the 1yr vaccine but that rarely occurs. I hope this helps! Please let me know if you have any other questions or concerns! If Sassy is strictly indoors, then the chances of her getting feline leukemia are quite low, so this is a vaccine that you could eliminate each year as long as Sassy maintains indoor status as the disease is transmitted via bites and scratches from other cats. If you have other cats in the household that go outdoors but Sassy does not, I would then keep Sassy updated on the leukemia vaccination as the other cats can potentially transmit the disease to her. Please let me know if you have any further questions or concerns and I would be more than happy to help you further!

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