Petco Text Logo
Petco Pet Logo

My puppy is lethargic and in pain after vaccinations. Is this normal?

Updated On September 23rd, 2025

Pet's info: Dog | French Bulldog | Female | unspayed | 1 month and 11 days old | 7.3 lbs

My 12 week old French bulldog puppy just got her 10-12 week vaccines and dewormer as well as heartgaurd and next guard I was told it was safe to give but now my puppy seems very lethargic and in pain around injection site even walking or picking her up make her cry out she does not want to get up at all and is very sleepy she was drooling a little bit(she has not drooled at all before Is she ok?

1 Answer

Most Helpful Answer

Image profile

Answered By Casey Smallwood

Veterinarian

Published on June 12th, 2018

I'm sorry to hear that Lettie is not feeling like her usual self! It should be noted that even normal puppy vaccines can lead to some side effects such as lethargy (decreased activity, tiredness), swelling or tenderness around the injection site and even mild nausea (possibly the drooling). That being said, rarely dogs can undergo an allergic reaction to vaccines which often show up as vomiting, collapse, and swelling of the face or other limbs. If these have been observed she should be seen by a veterinarian immediately. In regards to the safety of administering the Heartguard and Nexgard along with the vaccines, it is standard protocol to begin these preventative medications at this time and are safe to give to a puppy of Lettie's age. The most important thing going forward is to continue to monitor Lettie for any worsening or changing of her clinical signs. For example, if she starts to vomit becomes even more tired or lethargic, continues to want to eat or do anything after more than a day, or even have swelling around her face then she needs to be seen by a veterinarian immediately.

Vote icon

1Pet Parents found this answer helpful

image
Have A Vet Question?

Book an appointment with the pros – our expert vets are here to help.

Sponsored