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My cat is restless on Meclizine. Can I safely mix it with Cerenia?

Updated On September 23rd, 2025

Pet's info: Cat | Mixed Breed | Female | spayed | 16 years and 8 months old | 12 lbs

17 yr, 11.8 lb, cat has kidney dysfnct. On 1/24 she showed symptoms of inner ear prob or vestibular. My vet prescribed Cerenia but it can only be given 1x in 24 hrs and it wears off at about 12 hrs. So, vet added half a tab of meclizine to her regimen, but it seems like it makes her restless(?) Gets up and moves from sleeping place to place every 30m or so. Is it ok to mix the 2 drugs? Where can I look for effects of meclizine on cats. Symptoms are head tilt, falls, staggers. Appetite is fair.

1 Answer

Most Helpful Answer

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Answered By Jacqueline Nobles, DVM, DACVECC

Veterinarian, Board-Certified Emergency/Critical Care Specialist

Published on February 12th, 2017

Cerenia and meclizine have different mechanisms of action so it should not be a problem. If symptoms do not improve or worsen, you may want to discuss diagnostics and referral for disease in the brain.

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