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Puppy parvo shot: What side effects are normal, and when to worry?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Male | unneutered | 2 months and 28 days old | 3 lbs

What are the common side effects of parvo shots in puppies and when should I be concerned

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3 Answers

Most Helpful Answer

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Answered By Vanessa Yeager DVM MPH

Veterinarian

Published on September 17th, 2017

Hi and thanks for your post. Common side effects of vaccines are vomiting, diarrhea, swelling of the face and paws, hives, and extreme lethargy. Most vaccines reactions happen within the first 2 hours after administration, but can be up to 24-48 hours after the vaccine. You should be concerned if you notice any of the above 24-48 hours after the vaccine is given and please visit your nearest veterinary emergency clinic for any of these symptoms. I hope this helps and thanks for using Petco Pet Education Center, formerly Petcoach!

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Other Answers

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    Answered By Angel Alvarado, LVT

    Licensed Veterinary Technician

    Published on March 2nd, 2018

    You may see lethargy, loss of appetite or fever after vaccination. There may also be some pain or swelling at the site of injection. All these symptoms are relatively minor and usually resolve on their own in 24-48 hours. If symptoms are more severe or if you see swelling of the face and difficulty breathing, seek veterinary attention immediately.

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    Answered By Jenna Beyer, DVM, MBA, cVMA

    Veterinarian, Certified Veterinary Acupuncturist

    Published on August 13th, 2017

    Common signs associated with vaccine reaction include lethargy, vomiting, diarrhea, swollen muzzle, hives, or redness of the skin. If you see any of these symptoms, I recommend that you take Dazzy back to the vet ASAP for evaluation and possible steroids or epinephrine injection.

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