Why is my dog's fluconazole dose weekly? Is it harsh or liver-toxic?

Question

Why vet prescribed FLUCONAZOLE 150mg only once in a week instead of twice daily?Is that medicine is so harsh and strong?how can it cause liver failure. Pet's info: Dog | German Shepherd | Male | unneutered | 1 year old

Dr. Leigh, DVM · Accepted Answer

You will need to ask your vet why he/she prescribed it on a weekly dosing. The typical dose is every 12-24 hours. The cause of liver toxicity from fluconazole is unknown and the severity of liver injury ranges from mild and transient to acute liver failure. Most patients recover when the fluconazole is stopped. I have prescribed anti-fungal medications frequently and have never had any problems, especially if the dog is young and healthy. If you are concerned, your vet could check liver values a few days after starting the medication to make sure here is no increase.

Why is my dog's fluconazole dose weekly? Is it harsh or liver-toxic?

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