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Puppies sick after vaccine, suspected distemper. Booster or observe?

Updated On September 23rd, 2025

Pet's info: Dog | American Bulldog | Female | unspayed | 3 months and 3 days old | 17 lbs

hi..i have 2 puppies vaccinated with 5n1..they were active..one day after their 3rd vaccines they were having seizures and had to comeback to the vet and told me they were showing signs of distemper but on the serum test its shows negative. i still have adult dogs that completed their shots but still worried..my vet told me to give them booster shots asap..but i contacted other vets that told me not to yet and observe them first before giving them booster..what should i do?

1 Answer

Most Helpful Answer

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Answered By Destini R. Holloway, DVM

Veterinarian

Published on July 12th, 2017

I would most certainly observe them first before giving a potentially sick pet a vaccine, which will challenge their immune system almost immediately. I sure hope your puppies are ok and do not have distemper, because there is no real reliable cure for that. Also I am not sure what serum test was performed exactly, so more specifics are needed in that regard. A distemper test has to be ran at an outside lab and takes several days for results. Some possibilities here are that they both have distemper or are both having an abnormal reaction to the vaccine. If your adult dogs are acting normal, then I would not concern yourself about them at the moment. Your focus should be on the puppies, since they are the only ones that are symptomatic.

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