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My cat had Advantage, but I washed it off. Can I apply Frontline?

Updated On September 23rd, 2025

Pet's info: Cat | Mixed Breed | Male | neutered | 13 lbs

We put advantage on our cat, but washed it off with a bath (dish soap) in less than 12 hours. Can we apply frontline? Adult cat, 13 lbs. advantage was applied on Tuesday.

3 Answers

Most Helpful Answer

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Answered By Lindsey Edwards MVB, BSc, IVCA

Veterinarian

Published on May 6th, 2017

The two treatments are not closely related but I would still recommend 7-10days before reapplying. You do not mention why you washed off the advantage but I would recommend combing with a flea comb to remove fleas in the meantime if still present. It may be worth considering using comfortis or capstar tablets if he does not tolerate spot on medications (it is often the carrier and not the active ingredient that pets are sensitive to)

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    Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on

    No, it's not safe to apply Frontline on Bucky now. If it was on him for a couple of hours, it would have had time to dry and it's impossible to know how much was absorbed. Typically it's not safe to reapply flea treatments for at least another two weeks, so you will have to wait. I'm not sure why you washed off the Advantage, but I would not recommend using Frontline. I personally have seen resistance with it in my own pets, and I have many colleagues who have seen resistance with it as well. Advantage is a great spot on treatment, but if you want to use another brand, I recommend Revolution.

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    Answered By David Darvishian

    Veterinarian

    Published on December 15th, 2017

    Hi and thanks for using Petco Pet Education Center, formerly Petcoach! Sorry to hear about Toby. Yes, using a detergent or a soap based shampoo will strip off some of the product if not all since you did it one day after applying. Even after the product translocates over the body, bathing throughout the next 30 days can strip off product and decrease its effectiveness. I always advise using a shampoo that doesn't contain soaps and detergents for this reason. This type of shampoo won't strip the product off and decrease its activity. I think you can reapply Advantage but I would call Bayer and talk to their veterinary team for a consultation. It's free and they will give you the green light I think. Here's their number- 1800 008 757. Tell them you want to talk to tech support regarding applying Advantage. Good luck

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