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My dog has high BUN, creatinine, and liver enzymes. What's wrong?

Updated On September 23rd, 2025

Pet's info: Dog | Labrador Retriever | Male | 5 years and 11 months old

wanted to know what steps should I take to recover him from the followings heads:- BLOOD UREA NITROGEN (BUN)- 56.3 (5.00-25.00) SERUM CREATININE- 3.97 (0.6-1.3) SGOT/AST- 387.6 ( 0.80- 40.00)SGPT/ALT- 416.2 (25.00-118.00) S.ALKALINE PHOSPHATASE- 361.3(0.0-61.00)

1 Answer

Most Helpful Answer

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Answered By Christie Long, DVM

Veterinarian, Certified Veterinary Acupuncturist

Published on March 11th, 2017

Oscar's lab work is pointing to both liver and kidney issues. Unfortunately it's impossible to tell if this is truly a kidney problem or just dehydration secondary to other issues (not eating, not drinking, losing fluids through vomiting and diarrhea) without knowing the specific gravity of his urine. Possible causes these values could include liver diseases like viral or bacterial hepatitis, cancer of one or more abdominal organs (liver and kidney), or the bacterial disease leptospirosis. Unfortunately it's impossible to say for sure how to treat Oscar without more testing, and based on just these values alone. At the very least IV fluids may help to treat either dehydration or kidney disease, so you can talk to your veterinarian about starting there, but ultimately there are more questions to be answered.

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