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Gentamicin/Betamethasone Spray: Pet Skin Infection & Inflammation

Published on September 10th, 2024
Updated on October 15th, 2025
A topical combination medication used to treat inflammation and bacterial infections of the skin.
Gentamicin-Betamethasone Topical Spray

Summary

Used For:

Indicated for the treatment of superficial skin infections caused by bacteria sensitive to gentamicin

Brands:

Gentocin, Gentacalm

Species:

Dogs

Other names:

Betagen, GenOne, Gentaved

Drug type:

Antibiotic

Prescription required:

Yes

Pregnancy and lactation:

Safe use in breeding, pregnant, or lactating animals has not been established.

Side effects:

Unlikely if used according to directions
 

General description

These products contain a combination of gentamicin and betamethasone that are used to treat superficial skin infections and inflammation.

Uses

Indicated for the treatment of superficial skin infections caused by bacteria sensitive to gentamicin.

How it works

This combination medication provides anti-inflammatory and antibacterial activity that works by inhibiting protein synthesis in susceptible bacteria and reducing inflammation by suppressing inflammatory reactions.

Dosage

Your veterinarian may want to evaluate the lesion or perform a culture before treatment. Remove excessive hair and clean the affected area prior to treatment. Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. Administer 2 to 4 times daily for 7 days. Do not exceed 7 days unless directed by your veterinarian.

Forms

Gentamicin 0.57 milligrams per milliliter and Betamethasone 0.284 milligrams per milliliter in 60,120 or 240 milliliter bottles.

Storage information & handling

Store at room temperature away from heat and direct sunlight. Keep out of reach of children and animals.

What results can I expect?

Resolution of infection and inflammation for which the medication was prescribed.

Missed Dosage

If you miss an application, apply it as soon as you can. If it is time already for the next application, skip the missed application and go back to the normal schedule.

Overdose / acute toxicity

Although overdose/acute toxicity is unlikely, contact your veterinarian if your pet has accidentally ingested this medication.

Side effects

Unlikely if used according to directions, but may include: * Vomiting * Diarrhea Weight loss, anorexia, polydipsia and polyuria have occurred following parenteral or systemic use.

Contraindications

*Do not use in animals with previous sensitivity.

Drug interactions

Interactions with other drugs is not expected due to lack of significant systemic absorption.

Precaution

If ingested, or given at high doses or for prolonged periods of time, side effects related to the corticosteroid may be seen. The most common effect is an increase in the amount of drinking and urinating. Less commonly you may see an increased appetite and weight gain, panting, diarrhea, vomiting, and behavior changes. Avoid contact with the eyes. Avoid ingestion. Administration of recommended dose beyond 7 days may result in delayed wound healing. Clients should wash hands after application or wear gloves when applying.

Sources

*VIN Veterinary Drug Handbook* *Plumb’s Veterinary Drug Handbook*

Disclaimer
The information contained on this page is for educational purposes only. This medication should only be given under the advice of a veterinarian who has examined your pet under the laws applicable to your state of residence.

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