My cat is lethargic and staggering after amitriptyline. Is it an overdose?

Question

I recently increased my 10 pound cat’s amitriptyline from 16.2 mg twice a day to 16.2 mg 3 times a day due to a prolonged seizure episode. She is of course very lethargic now, seems to stagger a little when walking, seems despondent, seems to possibly not recognize us now, but we’re not sure about that. Is this dosage too much to tolerate, at least temporarily? This is the third day of the increased dosage. (My vet is not open on weekends, so we won’t be able to see her until tomorrow.). Pet's info: Cat | Mixed Breed | Female | spayed | 10 lbs

Dr. Strydom, DVM · Accepted Answer

Yes, that is way too much Amitriptyline and an overdose like this can be fatal. If she is having seizures that are not controlled then she needs to go to the ER. Amitriptyline shouldn't really even be given twice a day. It is not really a anti-seizure medication so I am not sure why your vet prescribed it. I suggest you refer to this information sheet for more information. The typical dose for a cat is 5-10mg once a day. https://www.petplace.com/article/drug-library/drug-library/library/amitriptyline-hcl-elavil-for-dogs-and-cats/

My cat is lethargic and staggering after amitriptyline. Is it an overdose?

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