Why is my cat acting crazy after taking Ariprazol & Gabapentin?

Question

Portifoy has been placed on Ariprazol and Gabapentin , along with probiotics and fish oil, as a temporary fix to signs of intestinal and bladder distress, as well as the loss of fur and lesions. After his first doses, he slept soundly and was calm. As soon as he woke up he began losing his control - I have to confine him to prevent him hurting himself, and he is screech meowing non stop. I tried giving him his second doses today and it's had no impact - if anything, he's worse. What do I do? Pet's info: Cat | Domestic Mediumhair | Male | neutered | 18 lbs

Sara Farmer, DVM · Accepted Answer

I'm wondering if Portifoy is on aripiprazole or Abilify, and if this is causing adverse signs due to serotonin syndrome. I can't find any information on dosing in cats, but I would imagine that like most antidepressants hyperexcitability might be a symptom. Amitriptyline is another common medication that is used as an antidepressant in situations like this that can cause odd behavior. I'd recommend talking to your vet about whether or not you should continue the medications. While gabapentin can cause sedation I think it would be less likely to cause these symptoms.

Why is my cat acting crazy after taking Ariprazol & Gabapentin?

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