Petco Text Logo
Petco Pet Logo

  • Two Easy Ways to Start Earning Rewards!

Is it safe to give my dog Trazodone after Anipryl for dementia?

Updated On September 23rd, 2025

Pet's info: Dog | Labrador Retriever | Male | neutered | 70 lbs

My dog stopped taking Anipryl 4 days ago. Now my vet wants me to give him trazodone tonight to try to treat his canine cognitive dementia. Everything I have read said to wait 2 weeks but she says that is not necessary. What is your opinion ? I am afraid of serotonin syndrome.

2 Answers

Most Helpful Answer

Image profile

Answered By Linda G, MS, DVM

Veterinarian

Published on January 30th, 2020

Hello. Most times you can give Anipryl along with Trazodone safely. On occasion, if the doses were/are high enough with both drugs, you might see serotonin syndrome. I am sure your veterinarian is quite aware of the doses used & is confident that Mitch will be fine. If you do see any unusual symptoms, agitation, muscle stiffness, distress, pacing, call your veterinarian. This is easily treated. Thanks for using Petco Pet Education Center, formerly Petcoach.

Vote icon

1Pet Parents found this answer helpful

Other Answers

  • Image profile

    Answered By Jennifer Summerfield, DVM CPDT-KA

    Veterinarian, Certified Dog Trainer

    Published on January 26th, 2020

    The safest bet is to allow a washout period of about two weeks before starting a new medication that affects serotonin levels, such as tramadol or trazodone. However, in some cases the new medication can be started sooner if the need is urgent, under close supervision by your veterinarian. I would recommend talking to your regular vet about this if you are concerned that your dog needs to start the new meds ASAP.

    Vote icon

    1Pet Parents found this answer helpful

See More Answers

Related Questions

Petco Pet Education Center
Health & Wellbeing
Why is my mouse's eye swollen, cloudy, and has pus?
Is your mouse's eye swollen, cloudy, and pussy? Dr. Melanie, a certified vet, discusses severe eye issues like infection or abscess, urging an immediate visit.
Updated on December 04, 2025
Petco Pet Education Center
Health & Wellbeing
What fish dog food helps dry skin if my dog eats Science Diet?
Is your dog's dry skin a concern? A certified vet offers expert advice on finding the best fish-based dog food alternatives to Science Diet for essential oils.
Updated on February 04, 2026
Petco Pet Education Center
Health & Wellbeing
My pet is breathing hard, not eating, and lethargic. What's wrong?
Is your rat breathing heavily, won't eat, and has no energy? A Licensed Vet Tech explains potential causes like infection and age, urging a vet visit for diagnosis.
Updated on December 04, 2025
Petco Pet Education Center
Health & Wellbeing
My pet has red spots all over. What's causing them and what to do?
See red spots on your pet? A certified Petco vet discusses common causes like allergies, infections, or mites, guiding you on diagnosis and treatment options.
Updated on December 04, 2025
Petco Pet Education Center
Health & Wellbeing
My small pet is limping and can't bear weight. Should I see a vet?
Is your pet limping and can't bear weight? A certified vet explains why a suspected fracture needs immediate diagnosis and safe pain relief. Get expert guidance.
Updated on December 04, 2025
Petco Pet Education Center
Health & Wellbeing
My dwarf hamster has a shut eye and is limping. What should I do?
Is your dwarf hamster struggling with eye issues or limping? A trusted vet offers expert guidance on symptoms and crucial next steps for comfort and care.
Updated on December 04, 2025
image
Have A Vet Question?

Book an appointment with the pros – our expert vets are here to help.

Book Now

Sponsored