My cat on phenobarbital had a seizure after ear drops. Interactions?

Question

My cat has seizures earlier this year. She was given phenobarbital and it resolved this problem... until now. She was just given prednisone by the vet and tresaderm ear drops, both for an ear situation (unrelated to seizures). Do any of these medications interact poorly? She had the seizure within sixty seconds of me putting in ear drops.

Dr. Melanie, BVSc MS · Accepted Answer

Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question. Poor girl! There is an interaction between phenobarbital and prednisone. The prednisone will not work as well when the animal is take phenobarbital. But that's not to say that this caused the seizure. It does happen that a seizure disorder requires increases in the anti-seizure medication over time because the lower dose isn't as effective anymore. I cannot find an interaction between tresaderm ear drops and phenobarbital, so it may be an unfortunate coincidence she had a seizure after getting the drops. I think the best thing for her is to take her into a vet immediately. I hope this helps!

My cat on phenobarbital had a seizure after ear drops. Interactions?

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