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Is 500mg Doxycycline 3x daily too high for my dog with lupus?

Updated On September 23rd, 2025

Pet's info: Dog | English Springer Spaniel | Male | neutered | 7 years and 6 months old | 60 lbs

My dog has been diagnosed with lupus and prescribed Niacinimide and Doxycycline. I'm worried that the dose of Doxycyline is too high - 500 mg three times daily, since everything I've read online indicates a much lower dose. Is this too much?

1 Answer

Most Helpful Answer

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Answered By Linda G, MS, DVM

Veterinarian

Published on November 27th, 2019

Hello. I wonder if perhaps the labels were mixed up. Normally, Doxycycline would be prescribed at 5-10 mg/kg ( 136-272 mg ) every 12 - 24 hours & the niacinamide 500 mg every 8 hours. Now if your vet actually sent home tetracycline, then the dose would be 500 mg every 8 hours. But if the Doxycycline was substituted for the Tetracycline, then the total dose should be less. I would definitely double check this with your veterinarian as soon as possible. Thanks for using Petco Pet Education Center, formerly Petcoach.

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