My cat is lethargic, drooling, peeing after Frontline. Is it a reaction?

Question

My cat is lethargic, drooling and peeing outside of the litter box after applying frontline. She had the same reaction last time and symptoms went away with time besides the urinating. Veterinary tests were inconclusive. She is 5 years old and this is only her second time receiving a frontline treatment. Pet's info: Cat | Mixed Breed | Female | spayed | 5 years and 10 months old | 8.5 lbs

Dr. Melanie, BVSc MS · Accepted Answer

Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question about Foot foot. I'm sorry she hasn't been well! So cats are very sensitive to flea treatments, and her symptoms seem to match up with flea treatment toxicity (except for urinating outside the litter box). It may be that the Frontline is causing her problems. I would wash off the Frontline now, give her a bath to get it off if you applied it within the last 24 hours. If it's been more than 24 hours, have her seen by a vet now. Depending on when you applied the Fronline, either wait a week (if the Frontline was applied in the last 24 hours) or two weeks since the application (if apply longer than 24 hours ago), then use a different flea treatment program like Revolution or Advantage. I would not use Frontline again. As for urinating outside the box, this could be due to feline idiopathic cystitis. Stress can bring this on, and a reaction to flea treatment can be stressful. Have her seen by a vet for this. I hope this helps!

My cat is lethargic, drooling, peeing after Frontline. Is it a reaction?

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