My dog's Frontline Plus isn't working. Should I switch to Advantix?
Updated On September 23rd, 2025
Pet's info: Dog | Mixed Breed Small (up to 22lb) | Male | neutered | 11 lbs
What is the difference between advantix and frontline plus? I've ordered frontline plus but am worried by some reviews that it doesn't work well. Should I use advantix instead? Right now, I'm using frontline spray.
4 Answers
Most Helpful Answer
Published on November 19th, 2019
The difference is that Advantix kills and repels fleas, ticks and mosquitoes, kills lice and also repels biting flies. In comparison, Frontline kills but does not repel fleas, ticks or lice and has no effect on mosquitoes or biting flies. Now, that being said, I've also had many cases where Advantix treated dogs still came in with ticks on them and dogs with Frontline had less occurrence of this happening. The spray is for spot treating and is different than using the monthly preventive. Either preventive is fine to use. If you notice ticks still or fleas, then switch to a different product would be my recommendation. I hope this helps!
1Pet Parents found this answer helpful
Related Answers from Veterinarians
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Published on May 31st, 2018
Yes, it's safe to use the Advantix flea collar, or other flea collars with the spot-on treatment. Keep in mind that controlling fleas on the dog is just half the battle. You will also need to try and kill the fleas in the environment to help keep them from getting reinfested. Below is a link to a good article that explains how to best get rid of fleas. https://www.petcoach.co/article/5-tips-to-get-rid-of-fleas I hope that helps and all goes well with the flea control.
1Pet Parents found this answer helpful
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Published on March 18th, 2019
Hello. There are a lot of really good flea & tick products out there, & for everyone one of them, you can find an untrue horror story online. Advantix ll has been around for over 10 years & if there were significant problems with this, it would be long gone by now. The oral products Bravecto & Nexguard, are also very, very good. The problem with the orals is that a similar product called Simparica, was associated in a slight increase in tremors or seizures in some dogs. But this has really not been the case with either Bravecto or Nexguard. Tick disease can be very serious, costly & dangerous. You have to weigh the very small chance of a reaction associated with one of the flea/tick products with the real possibility of a serious tick borne disease. I would rather not have to deal with nasty ticks on my pets or in my home. I regularly use Bravecto on some of my pets & the Seresto collars on others & have been very happy. Your vet, who is more familiar with your dogs overall health is an excellent source of what might be best for everyone. Hope this helps & that is a great picture of your guys. Thanks for using Petco Pet Education Center, formerly Petcoach.
1Pet Parents found this answer helpful
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Published on May 22nd, 2018
I recommend a product that kills both fleas and ticks instead of using two products. There are a number of products that can't be used together safely, which is why it's best to use just one. I recommend giving Addie either Frontline Plus or Nexgard. I hope this helps!
1Pet Parents found this answer helpful
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