Is FISS a concern for cats receiving multiple daily injections?

Question

My cat is taking subcutaneous amoxicillin+clavulanic acid injections daily (Sinulox) for 7 days. Should I worry he might develop feline injection site sarcoma (FISS)? I know it's more common in certain types of vaccines, but I read that it might also be associated with other injections, especially because it's not just one application, but several in a row. Thanks. Pet's info: Cat | Mixed Breed | Male | neutered

Linda G, MS, DVM · Accepted Answer

Hello. It is true that FISS can be associated with other injections besides vaccinations. We have seen sarcomas develop in areas where long-acting antibiotic & steroids have been injected, where suture material might remain, & from microchips. So, there might be a genetic predisposition for a sarcoma to form in these situations. If this is the only way to get the antibiotic into your cat, then varying the injection sites & doing this for the shortest period possible is recommended. But it is never a foregone conclusion that this will lead to sarcoma formation in Camis. Most cats do very, very well & never develop any problems. Thanks for contacting Petco Pet Education Center, formerly Petcoach.

Is FISS a concern for cats receiving multiple daily injections?

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