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My dog had surgery. Can I give Benadryl with other meds for licking?

Updated On September 23rd, 2025

Pet's info: Dog | English Mastiff | Female | spayed | 2 years and 4 months old | 150 lbs

Lina had a interdigital soft tissue mass removed Friday. We have both a donut and a soft cone. She gets distraught in the cone and moves so much that it made her foot bleed a little. She tolerates the donut but in certain positions she can still lick her paw. I just gave her rx nutri calm. Can I also give Benadryl? She already takes clorpheneramine for allergies and she took it at 8:00 pm...so wasn’t sure about more antihistamines.

1 Answer

Most Helpful Answer

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Answered By Jenna Beyer, DVM, MBA, cVMA

Veterinarian, Certified Veterinary Acupuncturist

Published on October 11th, 2020

Benadryl doesn’t usually make dogs very sleepy, but you could try it. I would do your best to keep the paw covered or have her wear the cone while you give her lots of reassurance. It can take a few days for them to adapt to the change in sight and hearing while wearing the cone, but after that they should go on like normal. I would also talk to your vet about other sedative options to be used as needed.

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