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My dog accidentally got a double dose of Simparica. Is she okay?

Updated On September 23rd, 2025

Pet's info: Dog | Boston Terrier | Female | spayed

I gave my dog a double dose of simparica. It's the up to 44 lb dose and shes 37

4 Answers

Most Helpful Answer

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Answered By Dr. Melanie, BVSc MS

Veterinarian

Published on June 15th, 2020

Thank you for contacting Petco Pet Education Center with your question about Rockelle. She should be ok. According to studies done by Zoetis who make Simparica, "In the overdose groups, transient and self-limiting neurological signs were observed in some animals: mild tremors at 3 times the maximum exposure dose and convulsions at 5 times the maximum exposure dose. All dogs recovered without treatment." You don't need to do anything. I hope this helps!

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165Pet Parents found this answer helpful

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    Answered By Jessica Keay, DVM

    Veterinarian

    Published on July 4th, 2018

    I am sorry to hear about your concern for Dixie! Studies have shown this drug to be fairly safe, with minimal side effects. In her case, she ingested about a 5mg per kg of body weight dosage. In research trials the drug was found to cause tremors and ataxia (wobbly walking) at 12 mg per kg and seizures at 20 mg per kg. Dixie is still well below these ranges, so unless she has an underlying seizure disorder we wouldn't expect any ill effects. I would just monitor her for GI upset and for tremors/drunken appearance/seizures. If these neurological symptoms occur, seek veterinary care, but we wouldn't expect them at this dose.

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    Answered By Penelope Graben, DVM

    Veterinarian

    Published on September 20th, 2021

    These products are overall very safe. In all likelihood, nothing will happen. In dogs with a low seizure threshold, it could contribute to seizures. We typically don't recommend inducing vomit unless we know the ingestion will cause harm, as vomit induction has it's own list of side effects. Monitor Karyn at home for 24 hours, and once that time has passed, I would not worry about it any longer.

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    Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on September 7th, 2019

    Charlie may be fine. According to their website: "In a margin of safety study, the veterinary medicinal product was administered orally to 8 week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28 day intervals for 10 doses. No adverse effects were observed at the maximum exposure dose of 4 mg/kg. In the overdose groups, transient and self-limiting neurological signs were observed in some animals: mild tremors at 3 times the maximum exposure dose and convulsions at 5 times the maximum exposure dose. All dogs recovered without treatment." I hope this helps!

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