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Is it safe to give my dog prednisone and dexamethasone together?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Small (up to 22lb) | Male | neutered | 11 years and 11 months old | 19 lbs

My dog was given a shot of dexamethosone for sever arthritis and 5 days of prednisone. I am questioning if you can give prednisone in addition to Dexamethosone. I was told also to withhold Rimadyl until a day after stoppingprednisone for a washout period. From what I have been reading, there should be a longer washout period before starting back the Rimadyl. What is your opinion?

1 Answer

Most Helpful Answer

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Answered By Jenna Beyer, DVM, MBA, cVMA

Veterinarian, Certified Veterinary Acupuncturist

Published on June 7th, 2020

It’s safe to use the prednisone with the dexamethasone shot, they are in the same class of steroids. I would wait more like 5-7 days between the last prednisone and the Rimadyl. Longer if Toby is prone to stomach upset or diarrhea. When used closely together, these two classes of medications can cause bleeding stomach ulcers.

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