My dog accidentally got a double dose of Trifexis. Is she safe?

Question

My dog was given her trifexis yesterday, but then my roommate didn’t know I gave it to her and he gave her another dose today. Will she be ok? She is a 72 lb GSD.

Dr. Strydom, DVM · Accepted Answer

This medication contains a combination of Spinosad and Milbemycin. Milbemycin can be used safely in dogs for heartworm prevention but has other uses as well, and can be given at a dose two to four times the normal dose that we use for heartworm prevention, so I would not worry at all about a higher then normal dose of that medication. Spinosad is used for flea prevention and is a relatively safe drug. The most common side effects seen with its use include a decreased appetite, vomiting, diarrhea, lethargy and rarely, in dogs with a low seizure threshold, possible seizures. Studies on research dogs showed no long term effects on dogs that were given TEN times the recommended dose. Side effects that were seen at that high dose included nausea, vomiting, a decrease in appetite and some diarrhea. She will probably be OK but all you can do at this stage is monitor her for any signs of toxicity. If any are noticed she needs to see a vet immediately.

My dog accidentally got a double dose of Trifexis. Is she safe?

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