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My dog takes NexGard and Heartgard. Can they cause seizures or side effects?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Small (up to 22lb) | Male | unneutered | 1 year and 2 months old | 6 lbs

can nexguard and heartguard create seizures?

1 Answer

Most Helpful Answer

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Answered By Andrea M. Brodie, DVM

Veterinarian

Published on May 8th, 2018

Reported side effects include vomiting, itching, diarrhea, lethargy and lack of appetite. Use with caution in dogs with a history of seizures. So if your dog has a history of seizures it might trigger a seizure. The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. It may be a good idea to have your dog tested for the Mdr1 defect, which is a genetic mutation that causes more side effects than usual in those dogs that carry the mutation when they receive a variety of medications, especially avermectins.

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