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My small dog ate a large dog's Simparica. Is it an emergency?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Female | 12 lbs

My 12 pound maltipoo snatched up and ate my 50# dog’s Simparica! It was for 44.1-88 pound dog. Should I be concerned???

1 Answer

Most Helpful Answer

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Answered By Angel Alvarado, LVT

Licensed Veterinary Technician

Published on May 6th, 2018

Simparica has a wide margin of safety, but Abby ingested 4 times her normal dose. You may see tremors or convulsions within the next 24 hours. These symptoms are typically self limiting and, in safety studies, resolved without treatment. Ideally, she should be examined at the nearest veterinary ER. Vomiting can be induced via injection followed by administration of activated charcoal to further reduce absorption. This is most effective when done within an hour or two of ingestion. There is no antidote for sarolaner (the active ingredient in Simparica) overdose, so treatment is largely supportive and symptomatic until recovery is complete. This may include IV fluids and medications to control tremors or convulsions if they develop.

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