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Can Vetoryl cause stroke-like symptoms in dogs with Cushing's?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Female | spayed | 6 years and 5 months old | 79 lbs

My dog diagnosed with cushings. Been on vetoryl for a month now. Have you ever heard of a dog having a mild stroke from this medication ? (I understand each dog is different) just wondering, because I think my pup has experienced a mild stroke as one half her body doesn’t seem to be functioning as normal.

1 Answer

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Answered By Laura Johnson VMD

Veterinarian

Published on May 6th, 2018

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Oh no! Poor Charlie! I have not heard of strokes being a side effect of Vetoryl (trilostane). It is very well tolerated and has significantly decreased the side effects for treating cushings compared to the older drug choice. Untreated cushings can cause clots though. I wonder if the stroke is unrelated and maybe he is experiencing a Vestibular event. Look at his eyes and see if they are moving abnormally. Dogs with Vestibular disease have abnormal eye movements, a head tilt, fall to one side, walk drunk, pant and drool because they are very dizzy. Vestibular disease is rarely fatal and can be managed. They tend to get better. I would encourage you to take Charlie to an emergency hospital to be evaluated. I wish you the best!

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