Is twice-daily Cephalexin for dog skin issues safe long-term?

Question

My dog weigh 39kg and vet prescribed cephalexin 500mg for twice a day I asked him but he didn't say anything but I am not getting is giving cephalexin twice a day good for him or not ir it should be given only once a day also while doing course all the Mark's go away clearly but after few months let's say 2 months it again started to come back then again we have to do this course so doing this course frequently after 2months for 15 days can harm his liver and reduce e his life span. See photos. Pet's info: Dog | German Shepherd | Male | unneutered | 3 years and 10 months old

Destini R. Holloway, DVM · Accepted Answer

Cephalexin should always be given every 12 hrs due to the half-life of the medication, and sometimes even every 6-8 hrs depending on the severity of the infection. There can be a build up of resistance to frequent use of antibiotics, so I would try to have a more in depth conversation with your vet about long term treatment options that can keep Bruno's skin barrier at optimal levels, such as daily fish oils, prescription diets, and medicated shampoo's. Bruno getting Cephalexin at the frequency that he has been getting it should no affect his liver in a negative way or reduce his lifespan, the main concern here is resistance to the antibiotics over time. Best of luck with your furry friend Bruno moving forward and managing his apparent skin allergies and skin infections. Take care!

Is twice-daily Cephalexin for dog skin issues safe long-term?

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