My dog's seizures returned on zonisamide. Should I up her dose?
Updated On September 23rd, 2025
Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | unspayed | 38 lbs
My dog started having seizures back in May. She since has been put on zonisamide twice a day to control her seizures. She went 6 weeks without having one since she was first put on zonisamide and had 3 today. Thinking she may have epilepsy. Would epilepsy prevail over the zonisamide? The vet sent her home with instructions to up her dosage of zonisamide. She is also diabetic and takes insulin but her levels were normal after the seizures. Any input?
2 Answers
Most Helpful Answer
Published on September 18th, 2019
Sometimes the anti-seizure medication needs to be increased to control the seizures, there is a chance they could get worse over time as you've seen. I think upping Mali's dosage is a good idea, and see how this helps her. If it doesn't, take her back into the vet.
1Pet Parents found this answer helpful
Related Answers from Veterinarians
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Published on April 1st, 2017
Hello. I am sorry that Bayleigh isn't feeling well. Decreasing any seizure medication can result in a seizure, and is never recommended without direct veterinary supervision. If you feel that the Zonisamide is resulting in negative side effects, chat with your vet about switching to either Pexion or Phenobarbital or Keppra. These are newer medications that may have less side effects for Bayleigh. Depending on her levels and the medications, your vet will tell you how to switch safely. Good luck with her!
1Pet Parents found this answer helpful
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