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My dog is itching. Is Benadryl safe with her current medications?

Updated On September 23rd, 2025

Pet's info: Dog | English Mastiff | Female | spayed | 1 year and 1 month old | 150 lbs

Lina has been itching like crazy and sees a dermatologist. She takes chlortrimitron and gets RX baths and got her first cytopoint injection today. She’s still miserable. Can she also take Benadryl just for tonight? She took 18 mg chlortrimitron at 8:00 pm

1 Answer

Most Helpful Answer

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Answered By Dr. Strydom, DVM

Veterinarian

Published on July 4th, 2019

Yes, you can do that as it has been almost 6 hours since her dose of chlorpheniramine. You don't want to dose them any closer together than that. If she is really 134 pounds she will need quite a large dose of Benadryl. The dose is 1-2 mg/# so essentially she needs at least 134mg. It comes in 25mg capsules. So, I suggest you give her 150mg or 6 capsules. People always balk at this but dogs take a much higher dose than humans due to the way they metabolize it so yes, I really did say 6 capsules. Hope this helps. Please post again if you have more questions. Take care!

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