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My dog is lethargic and not eating after starting Theophylline.

Updated On September 23rd, 2025

Pet's info: Dog | Cavalier King Charles Spaniel | Female | spayed | 21 lbs

My Cavalier has been on Gabapentin for syringomyelia for about 3 years with no issues. however, she was just prescribed Theophylline for possible COPD. This morning she is very lethargic and not eating or drinking. Is this a possible side effect of Theophylline, or is there a possible drug interaction?

1 Answer

Most Helpful Answer

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Answered By Rodrigo Roca, DVM

Veterinarian

Published on June 30th, 2019

Hello, sorry to hear about Ginger. Theophylline does have several interactions but gabapentin is not listed. Additionally, a primary side effect of this medication are GI distubances such as a decreased appetite, nausea, and vomiting. These GI signs usually resolve with long term administration, however, Ginger may need anti-nausea medications in order to get her to eat some food. Please contact your vetrinarian and inform then about her side effects so that they may prescribe medications to help with her GI side effects. Hope this helps and best of luck.

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