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Will Benadryl make my dog drowsy? Do dogs build up a tolerance?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Female | 5 years and 8 months old | 11 lbs

Does Benadryl cause drowsiness in dogs? Also if used daily do they tend to build up a tolerance so it doesn’t work as well long term if used daily?

1 Answer

Most Helpful Answer

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Answered By Catherine Stecyk

Veterinarian

Published on May 12th, 2019

Hello and thank you for reaching out to Petco Pet Education Center, formerly Petcoach. Benadryl can definitely cause drowsiness in some dogs, but this tends to be dose-dependent, meaning the higher the dose, the more likely a dog is to become drowsy. Some dogs are not very affected, though. We do not typically see a tolerance built up. The dose range is pretty wide, though, and Benadryl can be safely given up to 4 times per day. Depending on the reason that Kiwi is taking the Benadryl, I recommend consulting with your vet to see what dose & frequency they recommend. I hope this is helpful!

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