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My dog had a seizure. How long for phenobarbital to take effect?

Updated On September 23rd, 2025

Pet's info: Dog | Jack Russell Terrier | Female | spayed | 7 years and 10 months old | 13.22 lbs

My dog had patella surgery on Monday 15/4 and had a sezuire on Thursday. She has been sedated since. How long does it take for Gabapentin / phenobarbital take to get into the system? We are being told 2 weeks is this right?

1 Answer

Most Helpful Answer

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Answered By Catherine Stecyk

Veterinarian

Published on April 23rd, 2019

Hello and thank you for reaching out to Petco Pet Education Center, formerly Petcoach. I'm sorry to hear that Miley had a seizure. Yes, it can take 2-3 weeks for phenobarbital to hit the "steady state" of the drug, meaning get to the effective concentration in the body. If your veterinarian gave a 'loading dose' of phenobarbital first, Miley may reach the effective concentration sooner than 2 weeks. Gabapentin can take effect within a few hours, however this is not a very effective anti-seizure medication, and more of a chronic pain/sedative medication. I hope this is helpful!

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