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Is it safe to switch from Frontline Plus to K9 Advantix II for fleas?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Large (61lb +) | Male | neutered | 4 years and 11 months old | 90 lbs

Are used frontline plus on my dog about two weeks ago, but is not working to get rid of fleas on the dog. I purchased K9 Advantix two and would like to know if it’s safe to apply it to my dog now?

3 Answers

Most Helpful Answer

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Answered By Dr. Melanie, BVSc MS

Veterinarian

Published on April 4th, 2019

Since it's been two weeks, yes it's fine to apply the Advantix now. I would also give Barney Capster. It's a one time pill that starts killing fleas in 30 minutes. You will also have to disinfect the environment. Wash his bedding in hot soapy water, and vacuum the furniture and carpet surfaces. You can use a spray to kill fleas in the house, such as Indorex, or a flea bomb would work well to kill the fleas in the home. I hope this helps.

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Other Answers

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    Answered By Ricardo Fernandez, DVM

    Veterinarian, Veterinary Oncology Resident

    Published on November 2nd, 2017

    Thanks for using Petco Pet Education Center, formerly Petcoach! Generally, it is recommended to at least wait 2 weeks in between these products. If Molly is having a lot of fleas at this time, I would recommend that you try a product called Capstar which can basically kill a lot of fleas at once. You can use it every other day to effect and then either continue Frontline or switch to Advantage in 10 days. Good luck!

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    Answered By Andrea M. Brodie, DVM

    Veterinarian

    Published on May 27th, 2018

    I would wait about ten days from the day of application of the frontline. You will also need to treat your environment: get flea powder, put some in your vacuum cleaner bag and vacuum your house and furniture and also non-carpeted areas frequently to remove flea larvae and eggs which live off house dust., Dispose of the bag in the trash outside. Hot-wash all the pet's bedding, If you do this diligently for a few months in combination with the flea treatment, you will get rid of the fleas.

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