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Mixing puppy Benadryl & skin meds? Can I increase dose for hyperness?

Updated On September 23rd, 2025

Pet's info: Dog | Pembroke Welsh Corgi | Female | spayed | 2 months and 6 days old | 25 lbs

My puppy is taking 3cc of Benadryl three times a day and a capsule for her skin and coat (prescribed) once a day. Is it safe to put both of them in her food at the same time or should I give them to her separately throughout the day? Forgot to ask the vet today. Also she is crazy hyper and I really need her to calm down, can I up her dose on Benadryl?

1 Answer

Most Helpful Answer

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Answered By Lauren Jones VMD

Veterinarian

Published on March 6th, 2019

I’m assuming that the capsule prescribed to help with Mia’s skin and coat is a fatty acid fish oil (Omega 3 and/or 6) supplement. Yes, it is perfectly safe to put this with the Benadryl in her food at the same time. Try putting these medications in a small amount of food to assure that she eats them before feeding her the remainder of her meal. Only give the amount of Benadryl that your veterinarian directed - do not increase the dose. The Benadryl may make her a little bit groggy, but if it doesn’t, that’s ok. It’s normal for puppies to be a little hyper! Just offer her plenty of exercise and play time to try to burn off the extra energy. I hope this helps and that all goes well for Mia!

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